L-glutathion reduced; glutathione skin whitening pills; L-glutathion gnc CAS NO.70-18-8

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Oral glutathione supplementation has become very popular in the past decade.

Glutathione dietary supplements are known as L-glutathione, reduced glutathione or GSH. They come in pills, capsules, tablets, in powedered and liquid form, as sublingual drops or slow-melt tablets.

More and more people hear about glutathione (GSH) and its vital importance for proper detoxification, strong immune health, energy levels, endurance, muscle strength, anti-aging, master antioxidant role, and overall disease prevention.

People with various health concerns turn to glutathione pills, too, because they read in a health magazine or heard from TV gurus that raising glutathione would improve their condition.

Doctors who are aware of the benefits of elevated glutathione suggest glutathione supplementation to their patients, and/or prescribe NAC for them (while NAC is not glutathione, it is a pharmaceutical cysteine delivery system that raises GSH but can have some adverse side effects).

Oral glutathione supplementation is also very convenient – just take a pill once a day as you would do with a multivitamin. In our fast lives convenience is often as important as the end result of taking a supplement, if not more.

Our logic assumes that if a supplement is sold at all health food stores, pharmacies and online, and if it is advertised in mass media, it means the supplement must work well. 

However, most people, including medical professionals, are not aware of the fact that glutathione pills may not be very helpful to the body. (Out of all the decades of research only one recent study showed an increase in blood GSH levels in healthy adults with oral supplementation. See the details below.)

Only very small amounts of pre-manufactured glutathione are able to enter bloodstream. Most of it is lost in the digestive tract and cannot effectively raise intracellular glutathione levels in the most important detoxification organs, such as liver, kidneys and lungs, because glutathione is a small protein molecule and gets digested.

It is very important to educate yourself to be able to make wise choices about how to raise glutathione effectively – that is why it is important to look at scientific research.

There still aren’t that many studies done using oral glutathione, especially on human subjects. The few studies that were performed so far are mostly the studies on mice or rats, some on healthy adults with no acute or chronic diseases, and a few on adults and children with certain serious diseases such as cystic fibrosis and autism.

Let’s examine what science has to say about usefulness of glutathione supplements.

ORAL GLUTATHIONE IN STUDIES ON MICE AND RATS

Some studies done on mice and rats show increased GSH in tissue, blood plasma and organs (liver, kidney, heart, lung, brain, small intestine and skin) after administration of oral glutathione.

However, there are several interesting observations:

• Mice that were not previously depleted of glutathione showed an increase in plasma glutathione only in lungs.
• Mice that showed significant increase in glutathione concentration were chemically pretreated for 5 days to deplete their glutathione levels. Still, glutathione rose in all organs except in the liver where it is most needed for detoxification.
• The effect of raised glutathione lasted 3 hours on average.
• All mice and rats received glutathione supplementation in doses much higher than the typical 500 mg dosage in human glutathione pills: 100mg/kg of weight for mice. If we do a comparison with human dosages for an average adult weighing 70 kg (approx. 154 lbs.) one 500 mg glutathione pill contains only 7.5 mg of glutathione per kg of weight.

So, to achieve similar results an adult will have to be severely glutathione deficient and take a minimum of 14 glutathione pills. To maintain the result of raised glutathione an adult will have to take this many pills several times a day.